Urea Watch - Device for measuring blood urea level with iontophoresis method
Project funding and no: TÜBİTAK/TEYDEB -1501 / 3070005
Duration : 33 months / October 2006 – June 2009
The blood samples must be taken to determine the amount of urea in the blood for the patients with renal failure. For some patients, blood sampling is very uncomfortable, due to the pain caused by sampling process itself. Additionally, at the end of the treatment, stopping the bleeding is another problem especially for the patients with bleeding diathesis. In order to overcome this discomfort, it is necessary to develop a method to determine the amount of urea in the blood without taking blood sample from the patient.
Using the effect of electric field, the polar particles can be transferred into the bloodstream through the skin and from blood to the skin surface. Several studies have been done upon the determination of molecule concentrations in the blood by the method of iontophoresis and there are various patents relevant to the application. The international patent about the transferability of urea molecules out of the skin by iontophoresis method belongs to Mir Ar-Ge (Method for measuring blood urea level by reverse iontophoresis, WO03084604).
In this project, it is aimed to develop a new device to determine the amount of urea in human blood without any blood or biological samples and pain. Within this study, a device, which transports urea through the human skin to a polymeric gel by using the method of reverse iontophoresis and determines the amount urea in the blood, has been developed.